Researchers at Swansea University have developed a novel approach to testing biomaterials for bone regeneration, offering both speed and ethical refinement. Published in Bioactive Materials journal, and led by Dr. Zhidao Xia, a team from Swansea’s Medical School and Faculty of Science and Engineering has introduced a murine tibial periosteal ossification model that eliminates the need for traditional methods involving fractures or critical sized defects. In doing so, they significantly reduce animal suffering while enabling biomaterial evaluation in as little as 14 days, with cortical bone remodeling completed by 28 days. Dr. Xia explained, “Our invention bridges the gap between synthetic substitutes and donor bone. We’ve shown that it’s possible to create a material that is safe, effective, and scalable to meet global demand. This could end the reliance on donor bone and tackle the ethical and supply issues in bone grafting.” Alongside Swansea, several institutions worldwide contributed to this… read more